Carnosine-related dipeptides in the mammalian brain
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چکیده
منابع مشابه
EPR Spin-Trapping Studies of the Hydroxyl Radical Scavenging Activity of Carnosine and Related Dipeptides+
The electron paramagnetic resonance technique of spin trapping was employed to study the interaction of hydroxyl radicals with carnosine and related His-containing dipeptides. His and His-containing dipeptides were able to quench 49.1-94.996 of hydroxyl radicals produced by Fez+ and HzOz. The hydroxyl radical scavenging activity of dipeptides was in the order @-Ala < yaminobutyric acid (GABA) <...
متن کاملHydrolysis of carnosine and related compounds by mammalian carnosinases.
Comparative study of hydrolysis of carnosine and a number of its natural derivatives by human serum and rat kidney carnosinase was carried out. The rate of carnosine hydrolysis was 3-4-fold higher then for anserine and ophidine. The rate of homocarnosine, N-acetylcarnosine and carcinine hydrolysis was negligible by either of the enzymes used. Our data show that methylation, decarboxylation or a...
متن کاملCarnosine and Anserine in Mammalian Skeletal Muscle *
Two imidazole derivatives, carnosine and anserine, have been isolated from vertebrate skeletal muscle. Carnosine may be readily obtained from the ox (l), horse (2), pig (3), etc. Anserine, a methyl carnosine, has been isolated from birds, a reptile (4), fish (5), and certain mammals (6). The presence of the two compounds in muscles from the same animal has been adequately demonstrated only once...
متن کاملThe roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction
Objective(s): To benefit from reproduction and deal with challenges in the environmental conditions, animals must adapt internal physiology to maximize the reproduction rate. Maladaptive variations in the neurochemical systems and reproductive system can lead to manifestation of several significant mammalian reprocesses, including mammalian ovarian lifespan. RFamide-related peptide (RFRP, Rfrp)...
متن کاملQuantitative Studies of Carnosine and An- Serine in Mammalian Muscle* I. a Method for the Determination of Carnosine and Anserine
Carnosine was first isolated from beef muscle extract by Gulewitsch and Amiradsibi (10) in 1900, and has subsequently been shown to have a wide-spread occurrence in mammalian skeletal muscle. The investigations of Gulewitsch (8, 9), Baumann and Ingvaldsen (3), and Barger and Tutin (2) proved that carnosine is /3-alanyl-Lhistidine. Anserine was isolated from an extract of goose flesh by Ackerman...
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ژورنال
عنوان ژورنال: Progress in Neurobiology
سال: 1999
ISSN: 0301-0082
DOI: 10.1016/s0301-0082(99)00010-6